2005 Jun 10; 280(23):21763-72. Westwick JK, Cox AD, Der CJ, Cobb MH, Hibi M. Mithramycin selectively inhibits collagen-alpha 1(I) gene expression in human fibroblast. Kono H, Nakagami M, Rusyn I, Connor HD, Stefanovic B. Mechanisms of alcoholic liver disease: cytokines. Impact of burn injury on hepatic TGF-beta1 expression and plasma TGF-beta1 levels. Transforming growth factor-beta1 induces hepatocyte apoptosis by a c-Jun independent mechanism. Blood. 2003 Nov; 112(9):1383-94. Nat Rev Gastroenterol Hepatol. Age (Dordr). Studies with human cultured skin fibroblasts. Oh TG, Kim SM, Caussy C, Fu T, Guo J, Bassirian S, Singh S, Madamba EV, Bettencourt R, Richards L, Yu RT, Atkins AR, Huan T. Molecular and cellular mechanisms of liver fibrosis and its regression. Lackner JM, Jaccard J, Keefer L, Firth R, Carosella AM, Sitrin M. Magnetic resonance elastography predicts advanced fibrosis in patients with nonalcoholic fatty liver disease: a prospective study. Nat Rev Gastroenterol Hepatol. Liver Int. Exercise training attenuates age-associated diastolic dysfunction in rats. 1998 10; 275(4):C1058-66. 2018 09; 68(3):918-932. Dig Dis. Gut. Sidahmed E, Cornellier ML, Ren J, Askew LM, Li Y, Talaat N, Rapai MS, Ruffin MT, Turgeon DK. 2020 05; 158(6):1728-1744.e14. Cell Host Microbe. Dig Dis. 2017 Jun 16; 7:314-323. 2005 Sep; 289(3):G530-8. Am J Pathol. Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice. 1998 04; 274(4):G669-76. Gut. 2003 Apr; 27(4):726-31. David has 2 jobs listed on their profile. 2006 Aug; 44(2):420-9. 1996 Nov; 271(5 Pt 1):G780-90. Enomoto N, Ikejima K, Yamashina S, Enomoto A, Nishiura T, Nishimura T. Nuclear factor kappaB in proliferation, activation, and apoptosis in rat hepatic stellate cells. J Immunol. 2010 Feb; 16(2):181-90. 1995; (33):212-4. Fra, Fra away: the complex role of activator protein 1 in liver injury. 2000 Jul; 33(1):49-58. 1999 09; 277(3):G671-7. 2021; 12(3):891-920. Park CC, Nguyen P, Hernandez C, Bettencourt R, Ramirez K, Fortney L, Hooker J, Sy E, Savides MT, Alquiraish MH, Valasek MA. Leadership - Institute for Diabetes and Metabolic Health - UC San 2005 Apr; 115(4):849-59. Schrum LW, Bird MA, Salcher O, Burchardt ER, Grisham JW. 2021; 16(12):e0260721. Hepatology. Inokuchi S, Aoyama T, Miura K, Osterreicher CH, Kodama Y, Miyai K, Akira S. Hepatocarcinoma cells stimulate the growth, migration and expression of pro-angiogenic genes in human hepatic stellate cells. J Gastroenterol. Mol Pharmacol. The role of gut-derived bacterial toxins and free radicals in alcohol-induced liver injury. Cell. 2020 May 05; 56(5). Regulatory elements in the 5'-flanking region and the first intron contribute to transcriptional control of the mouse alpha 1 type I collagen gene. Stroke. Vasopressin inhibits type-I collagen and albumin gene expression in primary cultures of adult rat hepatocytes. I. TNF-alpha-induced liver injury: role of IKK, JNK, and ROS pathways. Wang P, Koyama Y, Liu X, Xu J, Ma HY, Liang S, Kim IH. Disruption of TAK1 in hepatocytes causes hepatic injury, inflammation, fibrosis, and carcinogenesis. TNFalpha is required for cholestasis-induced liver fibrosis in the mouse. 2011 Apr; 25(4):1133-44. Immortal activated human hepatic stellate cells generated by ectopic telomerase expression. Hepatology. J Biol Chem. 2007 Feb; 27(1):28-43. Rippe RA, Schrum LW, Stefanovic B, Sols-Herruzo JA. Expression of insulin-like growth factor I by activated hepatic stellate cells reduces fibrogenesis and enhances regeneration after liver injury. 2018 12; 68(6):2059-2061. 1994 Sep; 17(3):410-2. Clin Gastroenterol Hepatol. 2008 Aug; 42(5):349-61. People who share similar concepts with this person. 2019 09; 71(3):573-585. Recommendations for Probiotic Use--2015 Update: Proceedings and Consensus Opinion. Mazagova M, Wang L, Anfora AT, Wissmueller M, Lesley SA. 2012 Mar; 27 Suppl 2:65-8. Nat Rev Gastroenterol Hepatol. 2022 07 05; 34(7):978-990.e4. Differential expression of human lysyl hydroxylase genes, lysine hydroxylation, and cross-linking of type I collagen during osteoblastic differentiation in vitro. 2020 Apr; 4(4):606-626. 2020 12 15; 95(24):e3163-e3179. 2007 Apr; 132(4):1434-46. WebBrenners new job suits his eclecticism. J Clin Invest. What's new in liver fibrosis? The Crosstalk between Hepatocytes, Hepatic Macrophages, and Hepatic Stellate Cells Facilitates Alcoholic Liver Disease. Nucleic Acids Symp Ser. Hepatology. Meng F, Wang K, Aoyama T, Grivennikov SI, Paik Y, Scholten D, Cong M, Iwaisako K, Liu X, Zhang M, ?sterreicher CH, Stickel F, Ley K. Origin of myofibroblasts in liver fibrosis. Mixed-methods quantitative-qualitative study of 29 nonagenarians and centenarians in rural Southern Italy: focus on positive psychological traits. 2017 02; 152(3):598-607.e2. Expression of human immunodeficiency virus-1 in human colonic cells. Hepatology. New Approaches for Studying Alcoholic Liver Disease. Gastroenterology. Blockade of IL-17 signaling reverses alcohol-induced liver injury and excessive alcohol drinking in mice. Hepatic stellate cells and the reversal of fibrosis. Cardiovascular health of nonagenarians in southern Italy: a cross-sectional, home-based pilot study of longevity. Blood. Mechanisms of liver fibrosis and its role in liver cancer. J Immunol. 2012 Aug 31; 337(6098):1094-7. WebDavid Brenner is vice chancellor for health sciences at University of California San Diego. Hepatology. 2019 03; 156(4):1156-1172.e6. 2010 Sep; 139(3):987-98. Hepatology. Gastroenterology. 1987 Sep; 79(3):449-56. Gliotoxin-mediated apoptosis of activated human hepatic stellate cells. 2004 Oct; 121(2):159-70. Mol Cell Biol. 1997 10; 273(4):G795-803. 1995 Sep; 9(9):1157-65. Hepatology. Nephron. Hydrogen peroxide-induced liver cell necrosis is dependent on AP-1 activation. Nuclear extract preparations, DNase I footprinting, and mobility shift assays. Dr. David Brenner, UCSDs vice chancellor of health sciences, told the San Diego Union-Tribune on Tuesday that the dispute was never about Aisen. 2011 Jul; 179(1):189-98. 2013 Mar 01; 3(1):4-11. Am J Gastroenterol. 2020 02 13; 5(3). 2000 Jan; 118(1):90-100. 1993 Sep; 92(3):1336-48. Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications. PLoS One. Genetic labeling does not detect epithelial-to-mesenchymal transition of cholangiocytes in liver fibrosis in mice. Cell Metab. DavidBrenner, M.D., a distinguished physician-scientist, is Vice Chancellor for Health Sciences and Dean of the School of Medicine at the University of California, San Diego, effective February 1, 2007. WebBrenners wife, Jill Silverman Brenner, M.D., is a primary care internist and rheumatologist. Am J Physiol Gastrointest Liver Physiol. Proc Natl Acad Sci U S A. Alcohol Clin Exp Res. J Clin Invest. J Gastroenterol. 1999 Jan 06; 1453(1):161-74. 1995 Oct; 269(4 Pt 1):G591-9. Cell Metab. J Hepatol. 2000 Sep 29; 275(39):30597-604. 2003 May; 37(5):1043-55. Madsen DH, Leonard D, Masedunskas A, Moyer A, J?rgensen HJ, Peters DE, Amornphimoltham P, Selvaraj A, Yamada SS. Inhibition of NFkappaB in activated rat hepatic stellate cells by proteasome inhibitors and an IkappaB super-repressor. Xu J, Ma HY, Liang S, Sun M, Karin G, Koyama Y, Hu R. Gastric acid suppression promotes alcoholic liver disease by inducing overgrowth of intestinal Enterococcus. J Theor Biol. Am J Pathol. Nonalcoholic fatty liver disease with cirrhosis increases familial risk for advanced fibrosis. Therapy for hepatic fibrosis. Techniques to measure nucleic acid-protein binding and specificity. Hepatology. Nat Rev Gastroenterol Hepatol. 2018 06; 67(6):2150-2166. Role of mitochondrial inner membrane permeabilization in necrotic cell death, apoptosis, and autophagy. J Biol Chem. Norepinephrine induces calcium spikes and proinflammatory actions in human hepatic stellate cells. Signal transduction during liver regeneration. The recombination and integration of DNAs introduced into mouse L cells. 2022 10; 610(7931):366-372. Mol Ther Nucleic Acids. Stem Cells Cloning. Enomoto N, Schemmer P, Ikejima K, Takei Y, Sato N. Mice lacking inducible nitric oxide synthase have improved left ventricular contractile function and reduced apoptotic cell death late after myocardial infarction. 1998 Sep; 13(S1):S93-S95. Introducing PNAS Nexus. Inherited human cPLA(2alpha) deficiency is associated with impaired eicosanoid biosynthesis, small intestinal ulceration, and platelet dysfunction. 2014 Oct 28; 83(18):1653-60. Senderek J, Lassuthova P, Kabzinska D, Abreu L, Baets J, Beetz C, Braathen GJ. 2005; 23(3-4):255-63. Am J Physiol Cell Physiol. Am J Physiol Gastrointest Liver Physiol. Immunotherapy-based targeting of MSLN+ activated portal fibroblasts is a strategy for treatment of cholestatic liver fibrosis. Utility of magnetic resonance imaging versus histology for quantifying changes in liver fat in nonalcoholic fatty liver disease trials. Iimuro Y, Nishiura T, Hellerbrand C, Behrns KE, Schoonhoven R, Grisham JW. 2022 Oct 28; 11(11). 1992 Jun; 50(6):1203-10. 2003 Feb; 37(2):267-76. Regulation of alpha1(I) collagen messenger RNA decay by interactions with alphaCP at the 3'-untranslated region. Identification of small molecule activators of cryptochrome. Rhodes K, Rippe RA, Umezawa A, Nehls M, Brenner DA, Breindl M. PMID: 8065328; PMCID: PMC359121. Serum ?-glutamyltranspeptidase predicts all-cause, cardiovascular and liver mortality in older adults. Nat Commun. Intestinal a1-2-Fucosylation Contributes to Obesity and Steatohepatitis in Mice. 2005 Jun; 42(6):850-9. 2021 12 09; 12(1):7172. Scelzo A, Di Somma S, Antonini P, Montross LP. 2000 Nov 01; 28(21):4306-16. Collagen Formation Assessed by N-Terminal Propeptide of Type 3 Procollagen Is a Heritable Trait and Is Associated With Liver Fibrosis Assessed by Magnetic Resonance Elastography. This graph shows the total number of publications by year. Sam F, Sawyer DB, Xie Z, Chang DL, Ngoy S. Hepatic stellate cells as a target for the treatment of liver fibrosis. Promising Therapy Candidates for Liver Fibrosis. J Biol Chem. Itsumi M, Inoue S, Elia AJ, Murakami K, Sasaki M, Lind EF. Carethers will report directly to the chancellor and is part of the leadership team. Association Between Obesity and Discordance in Fibrosis Stage Determination by Magnetic Resonance vs Transient Elastography in Patients With Nonalcoholic Liver Disease. Cell Mol Gastroenterol Hepatol. 2014 May; 146(6):1513-24. J Biol Chem. 2019 01; 49(2):183-193. Cell Metab. 2000 Mar-Apr; 21(2):135-41. 1999 Oct 22; 274(43):30919-26. Am J Physiol. Am J Physiol Gastrointest Liver Physiol. Hepatology. In this role, he leads the School of Transforming growth factor-beta 1: there is regulation beyond transcription. In vivo activation of mitogen-activated protein kinases in rat intestinal neoplasia. Gene expression and cytokine and enzyme activation in the liver after a burn injury. Mutation of the 5'-untranslated region stem-loop mRNA structure reduces type I collagen deposition and arterial stiffness in male obese mice. Gut Microbiome-Based Metagenomic Signature for Non-invasive Detection of Advanced Fibrosis in Human Nonalcoholic Fatty Liver Disease. Gut. 1987 Dec 25; 262(36):17690-5. J Immunol. 2019 10; 68(10):1884-1892. 2020; 11:370. Am J Physiol Gastrointest Liver Physiol. Le TA, Chen J, Changchien C, Peterson MR. Fibroblast growth factor inducible 14 as potential target in patients with alcoholic hepatitis. Hepatology. 2002 Oct; 4(5):769-81. 2017 01 03; 127(1):55-64. J Biol Chem. Yang L, Magness ST, Bataller R, Rippe RA. 2015 Mar; 29(3):1043-55. Transforming growth factor B and hepatic fibrosis: cause or effect? Association between novel MRI-estimated pancreatic fat and liver histology-determined steatosis and fibrosis in non-alcoholic fatty liver disease. Activation of activating protein 1 during hepatic acute phase response. Krempen K, Grotkopp D, Hall K, Bache A, Gillan A, Rippe RA. J Hepatol. 1989 Feb 16; 337(6208):661-3. 1989 Jun 05; 264(16):9583-91. 1999 Mar; 31(2):173-9. 2005 Jan; 54(1):134-41. Kim YS, Schwabe RF, Qian T, Lemasters JJ. 1997 Sep; 17(9):5201-9. 1998 Sep; 13 Suppl:S39-50. 1990 Feb; 10(1):75-83. 2016; 7:47. Vuori will 2007 Dec; 52(12):3404-15. Hellerbrand C, Jobin C, Iimuro Y, Licato L, Sartor RB. Brenner edited blockbuster hits including 2012, Independence Day and Born On The Fourth Of July, for which he won his Oscar in 1990. Note that an individual publication can be assigned to more than one field. Report of the American Gastroenterological Association (AGA) Institute Obesity Task Force. 1998 Oct; 27(3):192-8. Cell Metab. As a result, the publication counts in this graph might add up to more than the number of publications the person has written. 2000 Jan; 48(1):39-44. DNA Cell Biol. NF-kappaB stimulates inducible nitric oxide synthase to protect mouse hepatocytes from TNF-alpha- and Fas-mediated apoptosis. 2010 Oct; 16(10):1152-6. McArdle PF, Kittner SJ, Ay H, Brown RD, Meschia JF, Rundek T, Wassertheil-Smoller S, Woo D, Andsberg G, Biffi A. Toso regulates differentiation and activation of inflammatory dendritic cells during persistence-prone virus infection. Primary Alcohol-Activated Human and Mouse Hepatic Stellate Cells Share Similarities in Gene-Expression Profiles. 2009; 120:361-8. c-Jun N-terminal kinase signaling in the pathogenesis of nonalcoholic fatty liver disease: Multiple roles in multiple steps. Stefanovic B, Hellerbrand C, Holcik M, Briendl M, Aliebhaber S. L-glutamine stimulates intestinal cell proliferation and activates mitogen-activated protein kinases. Westwick JK, Bielawska AE, Dbaibo G, Hannun YA. Black D, Bird MA, Hayden M, Schrum LW, Lange P, Samson C, Hatano E, Rippe RA. Loomba R, Seguritan V, Li W, Long T, Klitgord N, Bhatt A, Dulai PS, Caussy C. YIPF6 controls sorting of FGF21 into COPII vesicles and promotes obesity. 2018 01; 53(1):6-17. Caussy C, Bhargava M, Villesen IF, Gudmann NS, Leeming DJ, Karsdal MA, Faulkner C, Bao D, Liu A, Lo MT, Bettencourt R, Bassirian S. The Role of Fibrosis and Liver-Associated Fibroblasts in the Pathogenesis of Hepatocellular Carcinoma. Clin Gastroenterol Hepatol. Aliment Pharmacol Ther. Activation of Jun kinase is an early event in hepatic regeneration. Minimizing oxidative stress by gene delivery of superoxide dismutase accelerates regeneration after transplantation of reduced-size livers in the rat. Hepatology. Gastroenterology. Am J Physiol. 2016 11; 64(5):1547-1558. Cell Death Differ. Adler DH, Phillips JA, Cogan JD, Iverson TM, Schnetz-Boutaud N, Stein JA. Vollmann EH, Cao L, Amatucci A, Reynolds T, Hamann S, Dalkilic-Liddle I, Cameron TO, Hossbach M, Kauffman KJ, Mir FF, Anderson DG, Novobrantseva T, Koteliansky V. Mesothelin/mucin 16 signaling in activated portal fibroblasts regulates cholestatic liver fibrosis. Hepatitis C virus-induced oxidative stress suppresses hepcidin expression through increased histone deacetylase activity. Enteric dysbiosis associated with a mouse model of alcoholic liver disease. 1995 Jun; 21(6):303-7. Hepatology. 2020 Feb; 21(2):89-98. Kweon YO, Goodman ZD, Dienstag JL, Schiff ER, Brown NA, Burchardt E, Schoonhoven R. Akt protects mouse hepatocytes from TNF-alpha- and Fas-mediated apoptosis through NK-kappa B activation. Magness ST, Jijon H, Van Houten Fisher N, Sharpless NE. 2003 Feb; 124(2):445-58. Analysis of RNA transcripts for HLA class II genes in human small intestinal biopsies. J Hum Nutr Diet. FASEB J. Salicylate enhances necrosis and apoptosis mediated by the mitochondrial permeability transition. Hepatology. Nishio T, Iimuro Y, Nitta T, Harada N, Yoshida M, Hirose T, Yamamoto N, Morimoto T. c-Jun-N-terminal kinase drives cyclin D1 expression and proliferation during liver regeneration. 1998 Feb 15; 101(4):802-11. 1997 Jan 17; 272(3):1753-60. Yilmaz R, Weishaupt K, Valkadinov I, Knehr A. Wastewater sequencing uncovers early, cryptic SARS-CoV-2 variant transmission. Am J Physiol. Attenuated hepatic inflammation and fibrosis in angiotensin type 1a receptor deficient mice. Scholten D, Reichart D, Paik YH, Lindert J, Bhattacharya J, Glass CK. 2021 07 20; 118(29). USC undermined our ability to do research. 1997 Nov; 113(5):1589-98. 2007 Nov; 46(5):1443-52. 2004 Jun; 40(6):942-51. Effects of three superoxide dismutase genes delivered with an adenovirus on graft function after transplantation of fatty livers in the rat. 2003 Apr; 37(4):824-32. Am J Physiol. Bataller R, Gbele E, Parsons CJ, Morris T, Yang L, Schoonhoven R. Anandamide induces necrosis in primary hepatic stellate cells. Liver Transpl. 1998 Feb; 2(1):77-102, vi. 2017 09 15; 331:135-141. Recent advances in liver stem cell therapy. Patel NS, Hooker J, Gonzalez M, Bhatt A, Nguyen P, Ramirez K. The characteristics of activated portal fibroblasts/myofibroblasts in liver fibrosis. 2021 01; 335:113496. Biochem Biophys Res Commun. Am J Respir Cell Mol Biol. 2000 Apr 21; 275(16):12207-13. NFkappaB prevents apoptosis and liver dysfunction during liver regeneration. Gastroenterology. Hepatology. 1999 Aug; 14(8):1272-80. Nature. Nishiura T, Nishimura T, deSerres S, Godfrey V, Bradham CA, Nakagawa T. Role of Kupffer cells and gut-derived endotoxins in alcoholic liver injury. Tumor necrosis factor alpha inhibits collagen gene transcription and collagen synthesis in cultured human fibroblasts. 2020 12; 72(6):2182-2196. Hepatology. Proc Am Thorac Soc. Gene expression profiles during hepatic stellate cell activation in culture and in vivo. 2003 May; 73(1):44-52. This graph shows the total number of publications by year. Molecular mechanisms of alcohol-induced hepatic fibrosis. Kodama Y, Taura K, Miura K, Schnabl B, Osawa Y. Molecular pathogenesis of liver fibrosis. Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney. Front Biosci. Decaris ML, Li KW, Emson CL, Gatmaitan M, Liu S, Wang Y, Nyangau E, Colangelo M, Angel TE, Beysen C, Cui J, Hernandez C, Lazaro L. Magnetic Resonance Elastography vs Transient Elastography in Detection of Fibrosis and Noninvasive Measurement of Steatosis in Patients With Biopsy-Proven Nonalcoholic Fatty Liver Disease. 2008 Sep; 5(9):496-7. Synectin promotes fibrogenesis by regulating PDGFR isoforms through distinct mechanisms. Antifibrotic effects of a tissue inhibitor of metalloproteinase-1 antibody on established liver fibrosis in rats. Confocal microscopy of the mitochondrial permeability transition in necrotic and apoptotic cell death. 2006 Apr; 12(4):550-9. The role of TGFbeta1 in initiating hepatic stellate cell activation in vivo. 2002 Jul; 283(1):G204-11. 2014 Mar 07; 289(10):7082-7091. Gastroenterology. 2000 Jan 15; 28(2):641-7. Neutralization of Oxidized Phospholipids Ameliorates Non-alcoholic Steatohepatitis. 2010 Mar; 51(3):1027-36. Lang PA, Xu HC, Grusdat M, McIlwain DR, Pandyra AA. J Hepatol. Gastroenterology. 1994 Jun 21; 91(13):6030-4. Lab Invest. J Biol Chem. 2010 Oct; 52(4):1420-30. 2003 Oct; 23(5):386-96. Regulation of collagen alpha1(I) expression in hepatic stellate cells. Int J Biochem Cell Biol. 2006 Nov; 26(9):1138-47. 2002 Sep; 123(3):877-8. Human hepatic stellate cell isolation and characterization. Floch MH, Walker WA, Sanders ME, Nieuwdorp M, Kim AS. Dr. David Brenner, UCSDs vice chancellor of health sciences, told the Union-Tribune, Were glad theres been a settlement. CX3CL1-CX3CR1 interaction prevents carbon tetrachloride-induced liver inflammation and fibrosis in mice. 2009 Jul; 119(7):1858-70. c-Jun N-terminal kinase-1 from hematopoietic cells mediates progression from hepatic steatosis to steatohepatitis and fibrosis in mice. 2006 Jul 27; 82(2):241-50. Alcohol Clin Exp Res. Mol Cell Biol. Mol Metab. Uehara T, Bennett B, Sakata ST, Satoh Y, Bilter GK, Westwick JK. Hepatology. Activated hepatic stellate cells and portal fibroblasts contribute to cholestatic liver fibrosis in MDR2 knockout mice. 1999 Sep 15; 163(6):3474-83. 2015 Sep; 42(5):582-90. 2005 Dec; 42(6):1320-8. Nishio T, Koyama Y, Fuji H, Ishizuka K, Iwaisako K, Taura K, Hatano E. Collagenolysis-dependent DDR1 signalling dictates pancreatic cancer outcome. Thurman RG, Bradford BU, Iimuro Y, Knecht KT, Arteel GE, Yin M, Connor HD, Wall C, Raleigh JA, Frankenberg MV, Adachi Y, Forman DT. Post-transcriptional regulation of collagen alpha 1(I) mRNA in hepatic stellate cells. Lang A, Schrum LW, Schoonhoven R, Tuvia S, Sols-Herruzo JA. 2020 11 03; 32(5):878-888.e6. See more options in the Advanced Search tab. Adler DH, Cogan JD, Phillips JA, Schnetz-Boutaud N, Milne GL, Iverson T, Stein JA. 2009 Oct; 297(4):G726-34. Lopez-Sanchez I, Dunkel Y, Roh YS, Mittal Y, De Minicis S, Muranyi A, Singh S, Shanmugam K, Aroonsakool N, Murray F. TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis. Fat in nonalcoholic fatty liver disease ) collagen messenger RNA decay by interactions with at!, wang L, Baets J, Beetz C, Holcik M, Schrum LW, Stefanovic B. of... 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